Serine Proteases: Role in Human Health and Disease

Published by De Gruyter 2023

Serine Proteases

Role in Human Health and Disease

Edited by: Anil K. Sharma and Poonam Bansal

https://doi.org/10.1515/9783111325040

Overview
Contents

About this book

Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

Physiological role of serine proteases in initiation and progression of human diseases.
Includes respiratory disorders and cancer.
Strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

Author / Editor information

Dr. Poonam Bansal is currently working as an Assistant Professor in the Department of Biosciences and Technology at M.M. (Deemed to be University) Mullana (Ambala) Haryana, India. She is having 5 years of research experience including biosciences research, Teaching and Administration. Dr. Bansal have got her master’s (Biochemistry) and doctorate degree (Biochemistry) from Kurukshetra University, Kurukshetra. During her doctoral study, she worked on Phenotypic, Biochemical, Molecular and In silico Characterization of Pediococcus acidilactici NCDC 252 and screening it for its safety and efficacy assessment as per ICMR-DBT (INDIA) guidelines. Dr. Bansal has worked in diversified scientific areas ranging from Protein Biochemistry, Molecular Biology to Genomics, Proteomics, Next Generation Sequencing and Drug designing. She also published Genome Sequence of Pediococcus acidilactici NCDC 252 in National Center for Biotechnology Information (NCBI), 2019. She has published 28 research articles in peer reviewed, internationally repute journals and having 84 citations [H-Index~5;i10 index:4; cumulative impact factor: 26.201].

Dr. Anil K Sharma is presently working as a Professor and Head of the Biosciences and Technology Department since the year 2010. Previously he worked as a Senior Research Scientist in health sciences (2008-2010) and a Post-Doctoral Research Fellow (Molecular Biology) in the Microbiology and Immunology Department at UIC College of Medicine Chicago, IL, USA (2003-2008). He has more than 205 publications in peer-reviewed journals of national and international repute with h-Index of 36 (i₁₀~99) and a cumulative impact factor of his publications is more than 576.0 with more than 6815 citations. He has filed 17 patents with three of them recently published and 01 granted. 10 PhD scholars have already been passed out under his Guidance along with 22 Post Graduate students and 06 PhDs are currently pursuing under his guidance. His research interests are diverse but he has done tremendous progress contributing to Microbial, Environmental and Molecular biology fields, leading him to find a place consistently in the year 2019,2020 and 2021 in the list of global top 2% scientists recently released by Stanford University California, USA.

Topics

Frontmatter Publicly Available Download PDF	I
About the editors Publicly Available Download PDF	VII
Preface Publicly Available Download PDF	IX
Acknowledgments Publicly Available Download PDF	XI
Contents Publicly Available Download PDF	XIII
List of contributing authors Publicly Available Download PDF	XV
Chapter 1 Serine proteases: classification, catalytic mechanism, types, and industrial applications Poonam Bansal, Anil K. Sharma, Raman Kumar, Preeti Chanalia and Bhupesh Gupta Requires Authentication Unlicensed Licensed Download PDF	1
Chapter 2 Serine proteases and respiratory disorders Priti, Poonam Bansal and Sonali Sangwan Requires Authentication Unlicensed Licensed Download PDF	17
Chapter 3 Role of serine proteases in cancer progression and metastasis Raman Kumar, Poonam Bansal and Praveen Kumar Requires Authentication Unlicensed Licensed Download PDF	33
Chapter 4 Role of serine proteases in lung diseases: a view from acute and chronic lung infection complications Raman Kumar, Praveen Kumar and Poonam Bansal Requires Authentication Unlicensed Licensed Download PDF	51
Chapter 5 Inhibition of the serine exopeptidase DPP-IV as a means of mitigation of diabetic nephropathy Jagat C. Borah, Semim Akhtar Ahmed and Anuj Kumar Borah Requires Authentication Unlicensed Licensed Download PDF	65
Chapter 6 Serine proteases in arthritis Preeti Chanalia, Poonam Bansal and Dimpi Gandhi Requires Authentication Unlicensed Licensed Download PDF	83
Chapter 7 Serine protease HtrA: a promising therapeutic target to develop antimicrobial therapy Kapil Singh Narayan, Reenu Kashyap, Raman Kumar, Anil K. Sharma, Anil Panwar and Varruchi Sharma Requires Authentication Unlicensed Licensed Download PDF	101
Chapter 8 Potential targeted therapy for SARS-CoV-2: host serine proteases Shweta Dhanda, Kiran Bala, Priti, Anil K. Sharma, Anil Panwar and Varruchi Sharma Requires Authentication Unlicensed Licensed Download PDF	109
Chapter 9 Role of serine proteases in fertility Shweta Dhanda, Kiran Bala, Anil K. Sharma, Anil Panwar and Varruchi Sharma Requires Authentication Unlicensed Licensed Download PDF	129
Chapter 10 Serine protease inhibitors and its therapeutics Sonali Sangwan, Mahiti Gupta, Shikha Yashveer, Priti, Himani Punia, Jayanti Tokas and Bhupesh Gupta Requires Authentication Unlicensed Licensed Download PDF	141
Index Requires Authentication Unlicensed Licensed Download PDF	153

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Enzymologists, Biochemists, Medicinal Chemists, Microbiologists, Biologists, Pharmacists, Medical Biotechnologists.
Pages
- Front matter: 17
- Main content: 157
Illustrations
- Illustrations: 4
- Coloured Illustrations: 7
- Tables: 10
Keywords: Serine Protease Inhibitors; Digestion; Immune Responses; Blood Coagulation; Cancer; Respiratory Disorders.

eBook

Published: October 24, 2023
ISBN: 9783111325040

Hardcover

Published: October 24, 2023
ISBN: 9783111324982